There is a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to reduce afferent discomfort transmission and create analgesia. Hence, drugs like clonidine that focus on alpha-two receptors can affect the transmission of discomfort. Applies to clonidine: oral pill, oral https://grahamb183yqf9.dekaronwiki.com/user