Chemotherapy was potentiated by E7449 and solitary agent had sizeable antitumor exercise in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, likely as a result of TNKS inhibition. In step with this likelihood, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and drastically https://mauricez111unf2.sharebyblog.com/profile