Abstract = "Inhibition of deubiquitinase (DUB) action is usually a promising strategy for cancer therapy. VLX1570 is undoubtedly an inhibitor of proteasome DUB activity at present in medical trials for relapsed many myeloma. In this article we show that VLX1570 binds to and inhibits the activity of ubiquitin-specific protease-14 (USP14) https://noelf443cvn5.wikiannouncement.com/user